trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

Base Information

Chemical Name:trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine
CAS No.:170737-38-9
Molecular Formula:C₁₇H₃₁N₃O₄
Molecular Weight:341.451
Hs Code.:

Synonyms:trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

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Chemical Property of trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

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Technology Process of trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

There total 1 articles about trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 170737-37-8
trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

: 170737-38-9
trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In toluene; at 20 ℃; for 15h;
DOI:10.1248/cpb.47.1694

Reference yield: 57.0%

: 170737-38-9
trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

: 160132-94-5
tert-butyl trans-(4-aminocyclohexyloxy)acetate

Guidance literature:: With ammonium chloride; In tert-butyl alcohol; for 2h; Heating;
DOI:10.1248/cpb.47.1694

Reference yield:

: 170737-38-9
trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

: 174774-07-3
{4-[(5-carbamimidoyl-benzofuran-2-carbonyl)-amino]-cyclohexyloxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / aq. NH₄Cl / 2-methyl-propan-2-ol / 2 h / Heating

2: 84 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

3: H₂ / 10 percent Pd/C / 2-methyl-propan-2-ol / 7 h / Heating

With hydrogen; ammonium chloride; benzotriazol-1-ol; palladium on activated charcoal; In N,N-dimethyl-formamide; tert-butyl alcohol; 1: deprotection / 2: coupling / 3: Hydrogenolysis;
DOI:10.1248/cpb.47.1694