trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

Base Information

Chemical Name:trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine
CAS No.:170737-37-8
Molecular Formula:C₁₁H₂₁N₃O₂
Molecular Weight:227.307
Hs Code.:

Synonyms:trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

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Technology Process of trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

There total 1 articles about trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 96-31-1
N,N'-Dimethylurea

: 27489-62-9
trans-4-hydroxycyclohexylamine

: 170737-37-8
trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

Guidance literature:: With 4-methyl-morpholine; In 1,4-dioxane; toluene; for 5h; Heating;
DOI:10.1248/cpb.47.1694

Reference yield: 45.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 170737-37-8
trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

: 170737-38-9
trans-5-[4-[(tert-butoxycarbonyl)methyloxy]cyclohexyl]-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In toluene; at 20 ℃; for 15h;
DOI:10.1248/cpb.47.1694

Reference yield:

: 170737-37-8
trans-5-(4-hydroksycyclohexyl)-1,3-dimethylhexahydro-2-oxo-1,3,5-triazine

: 174774-09-5
trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyloxy]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / n-Bu₄NHSO₄; aq. NaOH / toluene / 15 h / 20 °C

2: 57 percent / aq. NH₄Cl / 2-methyl-propan-2-ol / 2 h / Heating

3: 84 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

4: H₂ / 10 percent Pd/C / 2-methyl-propan-2-ol / 7 h / Heating

5: TFA / 1 h / 20 °C

With sodium hydroxide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; ammonium chloride; benzotriazol-1-ol; trifluoroacetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 1: Substitution / 2: deprotection / 3: coupling / 4: Hydrogenolysis / 5: deprotection;
DOI:10.1248/cpb.47.1694