(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

Base Information

Chemical Name:(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate
CAS No.:1428526-56-0
Molecular Formula:C₁₇H₁₅N₄O₅P
Molecular Weight:386.304
Hs Code.:

Synonyms:(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

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Chemical Property of (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

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Technology Process of (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

There total 6 articles about (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1428526-54-8
diisopropyl (4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

: 1428526-56-0
(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 100-52-7
benzaldehyde

: 1428526-56-0
(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 48 h / 20 - 60 °C / Molecular sieve

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3: trimethylsilyl bromide / dichloromethane / 0 - 20 °C / Inert atmosphere

With trimethylsilyl bromide; ammonium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 1428526-56-0
(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C

2.1: sodium methylate / methanol / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4.1: trimethylsilyl bromide / dichloromethane / 0 - 20 °C / Inert atmosphere

With trimethylsilyl bromide; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;