(R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate

Base Information

• Chemical Name: (R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate
• CAS No.: 1202032-97-0
• Molecular Formula: C₂₂H₃₃O₅P
• Molecular Weight: 408.475

Synonyms:(R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate

Chemical Property of (R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate

Chemical Property:

Purity/Quality:

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Technology Process of (R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate

There total 12 articles about (R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

racemic 3-tert-butyl-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-ol oxide (1202032-95-8) + (+)-(1S,2R,5S)-menthylchloroformate (7635-54-3,7635-53-2) → (R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate (1202032-97-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 2.58333h;

Reference yield: 11.0%

C22H33O5P → (R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate (1202032-97-0)

Guidance literature:

With oxalyl dichloride; In dichloromethane; at 20 ℃; for 20.25h; Inert atmosphere;

DOI:10.1021/acs.joc.7b00491

Reference yield:

racemic 3-tert-butyl-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-ol oxide (1202032-95-8) + (+)-(1S,2R,5S)-menthylchloroformate (7635-54-3,7635-53-2) → (R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate (1202032-97-0) + (S)-3-phenyl-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl ((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl) carbonate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 5 - 60 ℃;

upstream raw materials:

racemic 3-tert-butyl-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-ol oxide

(+)-(1S,2R,5S)-menthylchloroformate

1,3-Dimethoxybenzene

tert-butyl(2,6-dimethoxyphenyl)(iodomethyl)phosphine oxide

Downstream raw materials:

BIBOP

(2S,2'S,3S,3'S)-MeO-BIBOP

(R)-3-tert-butyl-4-phenyl-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide

(2R,2'R,3R,3'R)-3,3'-di-tert-butyl-2,2'-diisopropyl-2,2',3,3'-tetrahydro-4,4'-bibenzo[d][1,3]oxaphosphole

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