Technology Process of (2S,4aR,6S,7R,8S,8aS)-7,8-bis(benzyloxy)-6-methoxy-2-(4-methoxyphenyl)hexahydropyrano[3,2-d][1,3]dioxine
There total 2 articles about (2S,4aR,6S,7R,8S,8aS)-7,8-bis(benzyloxy)-6-methoxy-2-(4-methoxyphenyl)hexahydropyrano[3,2-d][1,3]dioxine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S,4aR,7R,8R,8aR)-6-methoxy-2-(4-methoxyphenyl)hexahydropyrano[3,2-d][1,3]dioxine-7,8-diol;
With
tetra-(n-butyl)ammonium iodide;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
benzyl bromide;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
DOI:10.1021/jacs.9b11351
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (1S)-10-camphorsulfonic acid / acetonitrile / 2.5 h / 50 °C / 225.02 Torr / Inert atmosphere
2.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
2.2: 18 h / 0 - 20 °C / Inert atmosphere
With
(1S)-10-camphorsulfonic acid; tetra-(n-butyl)ammonium iodide;
In
N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jacs.9b11351
