7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide

Base Information

Chemical Name:7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide
CAS No.:1452510-70-1
Molecular Formula:BrH*C₂₀H₂₃F₃NO₃P
Molecular Weight:494.288
Hs Code.:

Synonyms:7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide

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Chemical Property of 7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide

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Technology Process of 7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide

There total 2 articles about 7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1452510-68-7
diethyl [7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]phosphonate

: 1452510-70-1
7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide

Guidance literature:: diethyl [7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]phosphonate; With trimethylsilyl bromide; In chloroform; at 20 ℃; for 72h; Inert atmosphere;

With ethanol; at 20 ℃; for 0.333333h;
DOI:10.1055/s-0033-1339173

Reference yield:

: 1452510-64-3
benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1452510-70-1
7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / Inert atmosphere

2.1: trimethylsilyl bromide / chloroform / 72 h / 20 °C / Inert atmosphere

2.2: 0.33 h / 20 °C

With trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; In methanol; chloroform;
DOI:10.1055/s-0033-1339173