benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1452510-64-3
Molecular Formula:C₃₂H₃₇F₃NO₅P
Molecular Weight:603.618
Hs Code.:

Synonyms:benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 1 articles about benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1452510-62-1
benzyl (2-(diethoxyphosphoryl)-1,1,1-trifluoro-5-phenylpent-4-yn-2-yl)(prop-2-yn-1-yl)carbamate

: 693-02-7
hex-1-yne

: 1452510-64-3
benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1452510-93-8
benzyl 6-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 60 ℃; for 3h; Reagent/catalyst; Overall yield = 77 %; regioselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1339173

Reference yield: 85.0%

: 1452510-64-3
benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1452510-68-7
diethyl [7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]phosphonate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 3h; Inert atmosphere;
DOI:10.1055/s-0033-1339173

Reference yield:

: 1452510-64-3
benzyl 7-butyl-3-(diethoxyphosphoryl)-5-phenyl-3-(trifluoromethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1452510-70-1
7-butyl-5-phenyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-3-yl-phosphonatehydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / Inert atmosphere

2.1: trimethylsilyl bromide / chloroform / 72 h / 20 °C / Inert atmosphere

2.2: 0.33 h / 20 °C

With trimethylsilyl bromide; palladium 10% on activated carbon; hydrogen; In methanol; chloroform;
DOI:10.1055/s-0033-1339173