2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide

Base Information

• Chemical Name: 2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide
• CAS No.: 103247-05-8
• Molecular Formula: C₁₉H₁₉Cl₂NO₂
• Molecular Weight: 364.271

Synonyms:2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide

Chemical Property of 2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide

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Technology Process of 2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide

There total 1 articles about 2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-Amino-2-(4-chloro-phenyl)-5,7-dimethyl-indan-4-ol (103246-81-7) + chloroacetyl chloride (79-04-9) → 2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide (103247-05-8)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 2h;

DOI:10.1021/jm00111a013

Reference yield: 86.0%

2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide (103247-05-8) + 1-(3-chlorophenyl)piperazine hydrochloride (13078-15-4,51639-49-7,65369-76-8) → N-[2-(4-Chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-2-[4-(3-chloro-phenyl)-piperazin-1-yl]-acetamide (103247-25-2)

Guidance literature:

With triethylamine; In acetonitrile; for 2h; Heating;

DOI:10.1021/jm00111a013

Reference yield: 84.0%

2-Chloro-N-[2-(4-chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-acetamide (103247-05-8) + 4-(3-methoxyphenyl)piperazine (16015-71-7) → N-[2-(4-Chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-2-[4-(3-methoxy-phenyl)-piperazin-1-yl]-acetamide (103247-28-5)

Guidance literature:

With triethylamine; In acetonitrile; for 2h; Heating;

DOI:10.1021/jm00111a013

upstream raw materials:

3-Amino-2-(4-chloro-phenyl)-5,7-dimethyl-indan-4-ol

chloroacetyl chloride

Downstream raw materials:

N-[2-(4-Chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-2-[4-(3-chloro-phenyl)-piperazin-1-yl]-acetamide

N-[2-(4-Chloro-phenyl)-7-hydroxy-4,6-dimethyl-indan-1-yl]-2-[4-(3-methoxy-phenyl)-piperazin-1-yl]-acetamide

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