(4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride

Base Information

Chemical Name:(4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride
CAS No.:1358013-55-4
Molecular Formula:C₂₁H₂₂N₂O₂*ClH
Molecular Weight:370.879
Hs Code.:

Synonyms:(4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride

Chemical Property:

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Technology Process of (4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride

There total 6 articles about (4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1191446-40-8
(4R,9aR)-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione

: 100-39-0
benzyl bromide

: 1358013-55-4
(4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride

Guidance literature:: (4R,9aR)-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione; benzyl bromide; With tetrabutylammomium bromide; potassium carbonate; In acetone; Reflux;

With hydrogenchloride; In diethyl ether; Cooling;
DOI:10.1016/j.ejmech.2011.11.032

Reference yield:

: 2-(4-toluenesulfonyloxy)phenylacetic acid methyl ester

: 1358013-55-4
(4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / acetonitrile / 2 h / Reflux

2.1: sodium hydroxide / ethanol / 0.17 h / 20 °C

3.1: tetrabutylammomium bromide; potassium carbonate / acetone / Reflux

3.2: Cooling

With pyridine; tetrabutylammomium bromide; potassium carbonate; sodium hydroxide; In ethanol; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2011.11.032

Reference yield:

: 1191446-39-5
(2R,αR)-α-(2-carbamoylpiperidinyl)-α-phenylacetic acid methyl ester

: 1358013-55-4
(4R,9aR)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 0.17 h / 20 °C

2.1: tetrabutylammomium bromide; potassium carbonate / acetone / Reflux

2.2: Cooling

With tetrabutylammomium bromide; potassium carbonate; sodium hydroxide; In ethanol; acetone;
DOI:10.1016/j.ejmech.2011.11.032