ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

Base Information

• Chemical Name: ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate
• CAS No.: 288590-36-3
• Molecular Formula: C₂₉H₂₄N₄O₃S₂
• Molecular Weight: 540.667
• Mol file: 288590-36-3.mol

Synonyms:ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

Chemical Property of ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

There total 5 articles about ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-aminothiazole-4-carboxylate (5398-36-7) + 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate (288590-32-9) → ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate (288590-36-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 17h;

DOI:10.1016/S0968-0896(00)00029-8

Reference yield:

trityl chloride (76-83-5) → ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate (288590-36-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 16 h / 20 °C

2: DCC / CH₂Cl₂ / 4 h / 20 °C

3: 88 percent / NEt₃ / dimethylformamide / 17 h / 50 °C

With triethylamine; dicyclohexyl-carbodiimide; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(00)01181-8

Reference yield:

2-(tritylamino)-thiazole-4-carboxylic acid ethyl ester (126533-37-7) → ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate (288590-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / CH₂Cl₂ / 4 h / 20 °C

2: 88 percent / NEt₃ / dimethylformamide / 17 h / 50 °C

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(00)01181-8

upstream raw materials:

2-aminothiazole-4-carboxylate

1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate

trityl chloride

2-(tritylamino)-thiazole-4-carboxylic acid ethyl ester

Downstream raw materials:

2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carboxylic acid

2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carboxylic acid ethyl ester

2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carboxylic acid

2-{[2-({2-[6-(trityl-amino)-hexanoylamino]-thiazole-4-carbonyl}-amino)-thiazole-4-carbonyl]-amino}-thiazole-4-carboxylic acid ethyl ester