1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate

Base Information

• Chemical Name: 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate
• CAS No.: 288590-32-9
• Molecular Formula: C₂₉H₂₁N₅O₂S
• Molecular Weight: 503.584
• Mol file: 288590-32-9.mol

Synonyms:1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate

Chemical Property of 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate

There total 4 articles about 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzotriazol-1-ol (2592-95-2) + 2-triphenylmethylamino-4-carboxy-1,3-thiazole (139355-13-8) → 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate (288590-32-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0968-0896(00)00029-8

Reference yield:

benzotriazol-1-ol (2592-95-2) + 2-(tritylamino)-thiazole-4-carboxylic acid ethyl ester (126533-37-7) → 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate (288590-32-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0223-5234(00)01181-8

Reference yield:

trityl chloride (76-83-5) → 1,2,3-benzotriazol-1-yl 2-triphenylmethylamino-1,3-thiazole-4-carboxylate (288590-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 16 h / 20 °C

2: DCC / CH₂Cl₂ / 4 h / 20 °C

With dicyclohexyl-carbodiimide; In pyridine; dichloromethane;

DOI:10.1016/S0223-5234(00)01181-8

upstream raw materials:

benzotriazol-1-ol

2-triphenylmethylamino-4-carboxy-1,3-thiazole

2-(tritylamino)-thiazole-4-carboxylic acid ethyl ester

trityl chloride

Downstream raw materials:

ethyl 2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

ethyl 2-[2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate

ethyl 2-[2-[2-(triphenylmethylamino)-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxamido]-1,3-thiazole-4-carboxylate