2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester

Base Information

Chemical Name:2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester
CAS No.:403611-80-3
Molecular Formula:C₃₀H₃₁NO₅
Molecular Weight:485.58
Hs Code.:

Synonyms:2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester

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Chemical Property of 2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester

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Technology Process of 2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester

There total 4 articles about 2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 170861-68-4
toluene-4-sulfonic acid 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethyl ester

: 403611-79-0
2-(4-hydroxyphenoxy)-2-methyl-3-phenylpropionic acid ethyl ester

: 403611-80-3
2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester

Guidance literature:: With caesium carbonate; at 55 ℃;
DOI:10.1021/jm0342616

Reference yield:

: 63650-08-8
(+)-ethyl 2-(4-benzyloxyphenoxy)propionate

: 403611-80-3
2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

1.2: 85 percent / tetrabutylammonium iodide / tetrahydrofuran / 14 h / -78 - 20 °C

2.1: 92 percent / H₂ / Pd/C / ethyl acetate / 20 h

3.1: 63 percent / Cs₂CO₃ / 55 °C

With hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm0342616

Reference yield:

: 100-39-0
benzyl bromide

: 403611-80-3
2-methyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenoxy}-3-phenylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

1.2: 85 percent / tetrabutylammonium iodide / tetrahydrofuran / 14 h / -78 - 20 °C

2.1: 92 percent / H₂ / Pd/C / ethyl acetate / 20 h

3.1: 63 percent / Cs₂CO₃ / 55 °C

With hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm0342616