2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene

Base Information

• Chemical Name: 2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene
• CAS No.: 211935-24-9
• Molecular Formula: C₃₃H₃₃NO₇
• Molecular Weight: 555.628
• Mol file: 211935-24-9.mol

Synonyms:2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene

Chemical Property of 2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene

There total 12 articles about 2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-benzyloxy-3,6-dimethoxybenzaldehyde (211935-25-0) + 2-Benzyloxy-1-methoxy-3-(3-nitropropyl)benzene (211935-26-1) → 2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene (211935-24-9)

Guidance literature:

With ammonium acetate; In acetic acid; treatment in a microwave oven;

DOI:10.1016/S0040-4039(98)01046-6

Reference yield:

6-allylguaicol (579-60-2) → 2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene (211935-24-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 86 percent / K₂CO₃ / acetone

2: 1.) O₃, 2.) Zn / 1.) MeOH, -40 deg C, 2.) AcOH

3: 100 percent / cetyltrimethylammonium bromide / aq. NaOH

4: 96 percent / MsCl, i-Pr₂NEt / CH₂Cl₂

5: 70 percent / NaBH₄ / methanol; tetrahydrofuran

6: 58 percent / NH₄OAc / acetic acid / treatment in a microwave oven

With sodium tetrahydroborate; ammonium acetate; cetyltrimethylammonim bromide; potassium carbonate; ozone; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; sodium hydroxide; dichloromethane; acetic acid; acetone;

DOI:10.1016/S0040-4039(98)01046-6

Reference yield:

O-allyl guaiacol (4125-43-3) → 2-Benzyloxy-3-[(Z)-4-(2-benzyloxy-3-methoxy-phenyl)-2-nitro-but-1-enyl]-1,4-dimethoxy-benzene (211935-24-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 91 percent / 24 h / 180 °C

2: 86 percent / K₂CO₃ / acetone

3: 1.) O₃, 2.) Zn / 1.) MeOH, -40 deg C, 2.) AcOH

4: 100 percent / cetyltrimethylammonium bromide / aq. NaOH

5: 96 percent / MsCl, i-Pr₂NEt / CH₂Cl₂

6: 70 percent / NaBH₄ / methanol; tetrahydrofuran

7: 58 percent / NH₄OAc / acetic acid / treatment in a microwave oven

With sodium tetrahydroborate; ammonium acetate; cetyltrimethylammonim bromide; potassium carbonate; ozone; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; sodium hydroxide; dichloromethane; acetic acid; acetone;

DOI:10.1016/S0040-4039(98)01046-6

upstream raw materials:

2-benzyloxy-3,6-dimethoxybenzaldehyde

2-Benzyloxy-1-methoxy-3-(3-nitropropyl)benzene

6-allylguaicol

O-allyl guaiacol