211935-26-1Relevant articles and documents
Synthesis of the bisbenzannelated spiroketal core of the γ-rubromycins. The use of a novel Nef-type reaction mediated by Pearlman's catalyst
Capecchi, Tanya,De Koning, Charles B.,Michael, Joseph P.
, p. 2681 - 2688 (2007/10/03)
The synthesis of the bisbenzannelated spiroketal core 6 of γ-rubromycin 1 from the substituted nitrostyrene 20 was achieved by using a novel Nef-type reaction mediated by Pearlman's catalyst. The precursor 28 was synthesised from readily prepared starting materials using Henry condensation chemistry. The product 6 was found to exist in two conformations in solution as shown by NMR spectroscopy.
Nitroalkenes as precursors to the aromatic spiroketal skeleton of γ- rubromycin. A Nef-type reaction mediated by Pearlman's catalyst
Capecchi, Tanya,De Koning, Charles B.,Michael, Joseph P.
, p. 5429 - 5432 (2007/10/03)
The first synthesis of the benzannelated spiroketal core of γ- rubromycin using Henry condensations and a novel Nef-type reaction induced by Pearlman's catalyst is described.