ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate

Base Information

Chemical Name:ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate
CAS No.:362054-89-5
Molecular Formula:C₂₅H₃₆N₂O₇
Molecular Weight:476.57
Hs Code.:

Synonyms:ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate

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Chemical Property of ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate

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Technology Process of ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate

There total 3 articles about ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: 362054-89-5
ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 - -50 °C

1.2: 81 percent / tetrahydrofuran; hexane / 3 h / -50 °C

2.1: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 2-chloro-4,6-dimethoxy-1,3,5-triazine; N-methylmorpholine / CH₂Cl₂ / 2 h / 0 °C

3.2: 2.65 g / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; n-butyllithium; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo010355g

Reference yield:

: 145060-76-0
tert-butoxycarbonyl-methyl-amino-acetic acid ethyl ester

: 362054-89-5
ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 - -50 °C

1.2: 81 percent / tetrahydrofuran; hexane / 3 h / -50 °C

2.1: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 2-chloro-4,6-dimethoxy-1,3,5-triazine; N-methylmorpholine / CH₂Cl₂ / 2 h / 0 °C

3.2: 2.65 g / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; n-butyllithium; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo010355g

Reference yield:

: 362054-84-0
ethyl 2-(N-tert-butoxycarbonyl-N-methyl)amino-3-benzoyl-4-pentenoate

: 362054-89-5
ethyl 2-[N-(2-tert-butoxycarbonylamino-3-methylbutanoyl)-N-methylamino]-3-benzoyloxy-4-pentenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

2.1: 2-chloro-4,6-dimethoxy-1,3,5-triazine; N-methylmorpholine / CH₂Cl₂ / 2 h / 0 °C

2.2: 2.65 g / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo010355g