(+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol

Base Information

• Chemical Name: (+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol
• CAS No.: 131285-44-4
• Molecular Formula: C₂₀H₃₂N₂O₄
• Molecular Weight: 364.485

Synonyms:(+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol

Chemical Property of (+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol

Chemical Property:

Purity/Quality:

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Technology Process of (+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol

There total 3 articles about (+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(-)-1-Deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol (57333-80-9) + 2,2-dimethoxy-propane (77-76-9) → (+)-2,5:3,4-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol (131285-45-5) + (+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol (131285-44-4)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; for 1h;

DOI:10.1002/ardp.19903231012

Reference yield:

D-ribose (50-69-1) → (+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol (131285-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2) NaBH₃CN / 1) EtOH, reflux, 1 h, 2) NH₄OAc/HCl-buffer (pH 3.5), 16 h

2: 41 percent / p-TsOH*H₂O / acetone / 1 h

With sodium cyanoborohydride; toluene-4-sulfonic acid; In acetone;

DOI:10.1002/ardp.19903231012

Reference yield:

N1,N1,6-trimethylbenzene-1,3-diamine (6406-67-3) → (+)-2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol (131285-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2) NaBH₃CN / 1) EtOH, reflux, 1 h, 2) NH₄OAc/HCl-buffer (pH 3.5), 16 h

2: 41 percent / p-TsOH*H₂O / acetone / 1 h

With sodium cyanoborohydride; toluene-4-sulfonic acid; In acetone;

DOI:10.1002/ardp.19903231012

upstream raw materials:

(-)-1-Deoxy-1-<(3-dimethylamino-4-methylphenyl)-amino>-D-ribitol

2,2-dimethoxy-propane

D-ribose

N¹,N¹,6-trimethylbenzene-1,3-diamine

Downstream raw materials:

(-)-2,3:4,5-Bis-O-(1-methylethyliden)-1-<(2,6-dichlorpyrimidin-4-yl)-(3-dimethylamino-4-methylphenyl)-amino>-1-deoxy-D-ribitol

(-)-2,3:4,5-Bis-O-(1-methylethyliden)-1-<(4,6-dichlorpyrimidin-2-yl)-(3-dimethylamino-4-methylphenyl)-amino>-1-deoxy-D-ribitol

(-)-1-<(2,6-dibenzyloxypyrimidin-4-yl)-(3-dimethylamino-4-methylphenyl)-amino>-2,3:4,5-bis-O-(1-methylethyliden)-1-deoxy-D-ribitol

(+)-6-<<2,3:4,5-Bis-O-(1-methylethyliden)-1-deoxy-D-ribit-1-yl>-(3-dimethylamino-4-methylphenyl)-amino>-1H,3H-pyrimidin-2,4-dion

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