(S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide

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Chemical Name:(S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide
CAS No.:1444778-48-6
Molecular Formula:C₂₆H₃₁N₃O₂
Molecular Weight:417.551
Hs Code.:

Synonyms:(S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide

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Chemical Property of (S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide

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Technology Process of (S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide

There total 6 articles about (S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 699-08-1
1-ethoxy-4-iodobenzene

: 1444778-48-6
(S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; methanol / 48 h / Reflux; Inert atmosphere

2.1: platinum(IV) oxide; acetic acid; hydrogen / 9 h / 20 °C / 2250.23 Torr

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane; acetonitrile / 15 h / 50 - 55 °C / Inert atmosphere

4.1: hydrogenchloride / isopropyl alcohol / 4 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 6 h / 20 °C

With hydrogenchloride; platinum(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; johnphos; sodium t-butanolate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1444780-57-7
(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

: 6914-79-0
1-cyano-cyclopropanecarboxylic acid

: 1444778-48-6
(S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide

Guidance literature:: 1-cyano-cyclopropanecarboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: 760150-51-4
4-(4-ethoxy-phenyl)-piperidine

: 1444778-48-6
(S)-1-cyano-cyclopropanecarboxylic acid (1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane; acetonitrile / 15 h / 50 - 55 °C / Inert atmosphere

2.1: hydrogenchloride / isopropyl alcohol / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 6 h / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; johnphos; sodium t-butanolate; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;