Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate

Base Information

Chemical Name:Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate
CAS No.:1234572-57-6
Molecular Formula:C₂₀H₁₉FN₈O₂S
Molecular Weight:454.488
Hs Code.:

Synonyms:Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate

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Chemical Property of Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate

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Technology Process of Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate

There total 5 articles about Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1234572-48-5
2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidine-4,5,6-triamine

: 108-23-6
isopropyl chloroformate

: 1234572-57-6
Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate

Guidance literature:: With pyridine; at 0 - 20 ℃; for 18h;

Reference yield:

: 2557-78-0
2-fluorothiophenol

: 1234572-57-6
Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C / Inert atmosphere

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 18 h / 90 °C

3: hydrogen; pyridine / palladium 10% on activated carbon / 17 h / 20 °C / 2625.26 Torr

4: pyridine / 18 h / 0 - 20 °C

With pyridine; hydrogen; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; XPhos; In ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 633328-40-2
3-iodo-1H-pyrazolo[4,3-b]pyridine

: 1234572-57-6
Propan-2-yl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-pyrazolo[4,3-b]pyridin-1-yl}pyrimidin-5-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C / Inert atmosphere

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 18 h / 90 °C

3: hydrogen; pyridine / palladium 10% on activated carbon / 17 h / 20 °C / 2625.26 Torr

4: pyridine / 18 h / 0 - 20 °C

With pyridine; hydrogen; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; XPhos; In ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;