3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Base Information

Chemical Name:3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate
CAS No.:1171190-99-0
Molecular Formula:C₁₇H₁₃ClN₂O₇
Molecular Weight:392.752
Hs Code.:

Synonyms:3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

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Chemical Property of 3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Chemical Property:

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Technology Process of 3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

There total 7 articles about 3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1171190-97-8
3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

: 1171190-99-0
3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Guidance literature:: With silver nitrate; In acetonitrile; at 20 ℃; for 22h;
DOI:10.1021/jm301905a

Reference yield:

: 1171190-83-2
3-(5-chlorofuran-2-yl)-5-hydroxy-4-phenyl-4,5-dihydroisoxazole-5-carboxylic acid

: 1171190-99-0
3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: boron trifluoride / 3 h / 0 - 20 °C

2: sodium carbonate / water; methanol / 2 h / Reflux

3: thionyl chloride / 2 h / Reflux

4: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice

5: silver nitrate / acetonitrile / 22 h / 20 °C

With thionyl chloride; boron trifluoride; sodium carbonate; silver nitrate; triethylamine; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm301905a

Reference yield:

: 1171190-85-4
methyl 3-(5-chlorofuran-2-yl)-5-hydroxy-4-phenyl-4,5-dihydroisoxazole-5-carboxylate

: 1171190-99-0
3-(nitroxy)propyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / water; methanol / 2 h / Reflux

2: thionyl chloride / 2 h / Reflux

3: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice

4: silver nitrate / acetonitrile / 22 h / 20 °C

With thionyl chloride; sodium carbonate; silver nitrate; triethylamine; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm301905a