3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Base Information

Chemical Name:3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate
CAS No.:1171190-97-8
Molecular Formula:C₁₇H₁₃BrClNO₄
Molecular Weight:410.652
Hs Code.:

Synonyms:3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

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Chemical Property of 3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

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Technology Process of 3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

There total 7 articles about 3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: C₁₄H₇Cl₂NO₃

: 627-18-9
1-bromo-3-propanol

: 1171190-97-8
3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;
DOI:10.1021/jm301905a

Reference yield: 60.0%

: 1171190-81-0
3-(5-chlorofuran-2-yl)-4-phenylisoxazole-5-carboxylic acid

: 627-18-9
1-bromo-3-propanol

: 1171190-97-8
3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Guidance literature:: 3-(5-chlorofuran-2-yl)-4-phenylisoxazole-5-carboxylic acid; With thionyl chloride; for 2h; Heating / reflux;

1-bromo-3-propanol; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

: 1171190-83-2
3-(5-chlorofuran-2-yl)-5-hydroxy-4-phenyl-4,5-dihydroisoxazole-5-carboxylic acid

: 1171190-97-8
3-bromopropyl [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: boron trifluoride / 3 h / 0 - 20 °C

2: sodium carbonate / water; methanol / 2 h / Reflux

3: thionyl chloride / 2 h / Reflux

4: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice

With thionyl chloride; boron trifluoride; sodium carbonate; triethylamine; In methanol; dichloromethane; water;
DOI:10.1021/jm301905a