(R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide
• CAS No.: 935263-25-5
• Molecular Formula: C₁₂H₁₄F₃NOS
• Molecular Weight: 277.31
• Mol file: 935263-25-5.mol

Synonyms:(R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide

Chemical Property of (R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide

There total 1 articles about (R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide (935263-25-5)

Guidance literature:

With copper(II) sulfate; In dichloromethane; for 36h;

Reference yield: 99.0%

(R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide (935263-25-5) + allyl bromide (106-95-6) → C15H20F3NOS (1015198-64-7)

Guidance literature:

With indium; sodium bromide; In water; at 20 ℃; for 12h; optical yield given as %de; diastereoselective reaction; Saturated solution;

DOI:10.1021/ol8001514

Reference yield: 99.0%

(R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide (935263-25-5) + 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (72824-04-5) → (R)-2-methyl-N-((R)-1-(4-(trifluoromethyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide

Guidance literature:

2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; With (S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

(R)-N-(4-trifluoromethylbenzylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; methanol; at 20 ℃; for 40h; Inert atmosphere;

DOI:10.1039/c5ob00322a

upstream raw materials:

4-Trifluoromethylbenzaldehyde

(R)-2-methylpropane-2-sulfinamide

Downstream raw materials:

C₁₅H₂₀F₃NOS

(R(S))-N-((R,E)-1-(4-(trifluoromethyl)phenyl)hex-2-enyl)-2-methylpropanesulfinamide

C₁₃H₁₂F₃NO

(2R,3R)-1-((R)-tert-butylsulfinyl)-2-(4-(trifluoromethyl)phenyl)-3-vinylaziridine