methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate hydrochloride

Base Information

• Chemical Name: methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate hydrochloride
• CAS No.: 1422507-94-5
• Molecular Formula: C₂₈H₂₈ClN₅O₅*ClH
• Molecular Weight: 586.475

Synonyms:methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate hydrochloride

Chemical Property of methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate hydrochloride

There total 14 articles about methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-17-{[2-(trimethylsilyl)ethoxy]methyl}-8,17,19-triazatricyclo[ 14.2.1.02,7]nonadeca-1(18),2,4,6,12,16(19)-hexaen-5-yl]carbamate → methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.02,7]nonadeca-1(18),2,4,6,12,16(19)-hexaen-5-yl]carbamate hydrochloride (1422507-94-5)

Guidance literature:

With hydrogenchloride; rac-cysteine; In 1,4-dioxane; at 20 - 75 ℃; Inert atmosphere;

Reference yield:

1-(3-chlorophenyl)-3-iodopropan-1-ol (1422509-95-2) → methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.02,7]nonadeca-1(18),2,4,6,12,16(19)-hexaen-5-yl]carbamate hydrochloride (1422507-94-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 75 °C / Inert atmosphere

2: triethylamine / 1,4-dioxane / 80 - 110 °C / Inert atmosphere

3: rac-cysteine; hydrogenchloride / 1,4-dioxane / 20 - 75 °C / Inert atmosphere

With hydrogenchloride; rac-cysteine; potassium carbonate; triethylamine; In 1,4-dioxane; acetonitrile;

Reference yield:

methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate (1422387-43-6) → methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.02,7]nonadeca-1(18),2,4,6,12,16(19)-hexaen-5-yl]carbamate hydrochloride (1422507-94-5)

Guidance literature:

Multi-step reaction with 7 steps

1: zinc; ammonium chloride / methanol / 4 h / 60 °C / Sealed tube

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / ethyl acetate / 1.08 h / -10 - 20 °C / Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; toluene-4-sulfonic acid / dichloromethane / 1.5 h / 40 °C / Inert atmosphere

4: 1,1,1,3',3',3'-hexafluoro-propanol / 1 h / 150 °C / Microwave irradiation

5: potassium carbonate / acetonitrile / 75 °C / Inert atmosphere

6: triethylamine / 1,4-dioxane / 80 - 110 °C / Inert atmosphere

7: rac-cysteine; hydrogenchloride / 1,4-dioxane / 20 - 75 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; rac-cysteine; 1,1,1,3',3',3'-hexafluoro-propanol; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; acetonitrile;

upstream raw materials:

1-(3-chlorophenyl)-3-iodopropan-1-ol

methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1H-imidazol-5-yl)-3-nitrophenyl)carbamate

methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate

tert-butyl N-[(1S)-1-(4-{2-amino-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1422507-94-5 methyl N-[(12E,15S)-15-[6-(3-chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-9-oxo-8,17,19-triazatricyclo[ 14.2.1.0^2,7]nonadeca-1⁽¹⁸⁾,2,4,6,12,16⁽¹⁹⁾-hexaen-5-yl]carbamate hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send