3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Base Information

Chemical Name:3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one
CAS No.:1312938-82-1
Molecular Formula:C₃₁H₂₉N₃O₄
Molecular Weight:507.589
Hs Code.:

Synonyms:3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

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Chemical Property of 3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

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Technology Process of 3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

There total 3 articles about 3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1312939-06-2
C₃₀H₃₁N₃O₃

: 530-62-1
1,1'-carbonyldiimidazole

: 1312938-82-1
3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1312938-83-2
4'-[(1-benzyl-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]biphenyl-2-carbonitrile

: 1312938-82-1
3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 1 h / 40 °C

2.2: 16 h / 90 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 °C

With hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1312939-05-1
4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydropyridin-3-yl)methyl]biphenyl-2-carbonitrile

: 1312938-82-1
3-{4'-[(1-benzyl-6-methyl-2-oxo-4-propoxy-1,2-dihydro pyridin-3-yl)methyl]biphenyl-2-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 1 h / 40 °C

1.2: 16 h / 90 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; N,N-dimethyl-formamide;