2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester

Base Information

• Chemical Name: 2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester
• CAS No.: 1240453-51-3
• Molecular Formula: C₁₈H₁₈O₆
• Molecular Weight: 330.337
• Mol file: 1240453-51-3.mol

Synonyms:2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester

Chemical Property of 2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester

There total 2 articles about 2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-(benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde (18234-41-8) + ethyl acrylate (140-88-5,9003-32-1) → 2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester (1240453-51-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In 1,4-dioxane; water; at 20 ℃; for 0.75h;

DOI:10.1007/s10593-010-0466-5

Reference yield:

5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one (15771-06-9) → 2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester (1240453-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 70 °C

2: 1,4-diaza-bicyclo[2.2.2]octane

With 1,4-diaza-bicyclo[2.2.2]octane; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; 2: |Baylis-Hillman Reaction;

DOI:10.1515/hc-2014-0197

Reference yield: 68.0%

1H-imidazole (288-32-4) + 2-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)hydroxymethyl]acrylic acid ethyl ester (1240453-51-3) → C21H20N2O6

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; at 70 ℃; for 5h;

DOI:10.1515/hc-2014-0197

upstream raw materials:

5-(benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde

ethyl acrylate

5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one

Downstream raw materials:

(E)-3-[5-benzyloxy-4-oxo-4H-pyran-2-yl]-2-[(imidazol-1-yl)methyl]acrylic acid ethyl ester

(E)-2-[(benzimidazol-1-yl)methyl]-3-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)]acrylic acid ethyl ester

(E)-3-[(5-benzyloxy-4-oxo-4H-pyran-2-yl)]-2-[(3-methylpyrazol-1-yl)methyl]acrylic acid ethyl ester

2-[acetyloxy(5-benzyloxy-4-oxo-4H-pyran-2-yl)methyl]acrylic acid ethyl ester