3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester
• CAS No.: 225115-85-5
• Molecular Formula: C₂₉H₄₄N₂O₁₀
• Molecular Weight: 580.676
• Mol file: 225115-85-5.mol

Synonyms:3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester

Chemical Property of 3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester

There total 1 articles about 3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Diethyl iminodiacetate (6290-05-7) + 3,5-Bis(brommethyl)benzoesaeure-tert-butylester (156597-80-7) → 3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester (225115-85-5)

Guidance literature:

With potassium carbonate; In acetonitrile; Ambient temperature; sonication;

DOI:10.1021/jo982397j

Reference yield: 91.0%

3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester (225115-85-5) → sodium 3,5-bis(bis((ethoxycarbonyl)methyl)aminomethyl)benzoate

Guidance literature:

With trifluoroacetic acid; for 2.5h; Ambient temperature;

DOI:10.1021/jo982397j

Reference yield:

3,5-bis-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzoic acid tert-butyl ester (225115-85-5) → [(3-[(bis-ethoxycarbonylmethyl-amino)-methyl]-5-{2-[2-(2-heneicosa-8,10-diynoylamino-ethoxy)-ethoxy]-ethylcarbamoyl}-benzyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester (225115-95-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / TFA / 2.5 h / Ambient temperature

2: 90 percent / BOP, Et₃N / acetonitrile / 12 h / Ambient temperature

3: 97 percent / TFA / 2.5 h / Ambient temperature

4: 89 percent / BOP, Et₃N / acetonitrile

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In acetonitrile;

DOI:10.1021/jo982397j

upstream raw materials:

Diethyl iminodiacetate

3,5-Bis(brommethyl)benzoesaeure-tert-butylester

Downstream raw materials:

ethyl 2-(((5-(N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamoyl)-3-((bis(ethoxycarbonyl)methylamino)methyl)phenyl)methyl)(ethoxycarbonyl)methylamino)acetate

[(3-[(bis-ethoxycarbonylmethyl-amino)-methyl]-5-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyl}-benzyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester

ethyl 2-(5-(N-(2-(2-(2-(2,3-diaminopropanoylamino)ethoxy)ethyl)carbamoyl)-3-bis(ethoxycarbonyl)methyl)amino)acetate

({3-(2-{2-[2-(2,3-bis-tert-butoxycarbonylamino-propionylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-5-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester