4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide

Base Information

• Chemical Name: 4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide
• CAS No.: 82099-14-7
• Molecular Formula: C₂₆H₂₉N₃O₃S₂*HI
• Molecular Weight: 623.579
• Mol file: 82099-14-7.mol

Synonyms:4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide

Chemical Property of 4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide

There total 8 articles about 4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide (82098-93-9) + methyl iodide (74-88-4) → 4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide (82099-14-7)

Guidance literature:

In acetone; Ambient temperature;

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → 4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide (82099-14-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 70 percent / H₂ / Raney-nickel / methanol / Ambient temperature

2: 1.) NaNO₂/conc. HCl; 2.) CuCN/NaCN / 1.) H₂O, 0-5 deg C; 2.) benzene, 0-5 deg C, 30 min; room temp., 4 h

3: 63 percent / PBr₃ / CHCl₃ / 1.5 h / Heating

4: 1.) KI; 2.) Na / 1.) EtOH, reflux; 2.) EtOH, reflux, 5 h

6: 67.5 percent / benzene / Ambient temperature

7: 100 percent / H₂S (gas), TEA / pyridine / Ambient temperature

8: 90 percent / acetone / Ambient temperature

With hydrogenchloride; TEA; hydrogen sulfide; sodium cyanide; hydrogen; sodium; phosphorus tribromide; potassium iodide; sodium nitrite; nickel; In pyridine; methanol; chloroform; acetone; benzene;

Reference yield:

4-(2-bromoethyl)benzonitrile (72054-56-9) → 4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzimidic acid methyl ester; hydriodide (82099-14-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) KI; 2.) Na / 1.) EtOH, reflux; 2.) EtOH, reflux, 5 h

3: 67.5 percent / benzene / Ambient temperature

4: 100 percent / H₂S (gas), TEA / pyridine / Ambient temperature

5: 90 percent / acetone / Ambient temperature

With TEA; hydrogen sulfide; sodium; potassium iodide; In pyridine; acetone; benzene;

upstream raw materials:

4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide

methyl iodide

4-(2-bromoethyl)benzonitrile

2-(4-nitrophenyl)ethanol

Downstream raw materials:

4-[3-(Naphthalene-1-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-benzamidine; hydriodide