dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate

Base Information

Chemical Name:dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate
CAS No.:98890-12-1
Molecular Formula:C₂₈H₂₉N₅O₁₀
Molecular Weight:595.566
Hs Code.:

dimethyl O<sup>2'</sup>-benzoyl-O<sup>7'</sup>-(tetrahydropyran-2-yl)griseolate

Synonyms:dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate

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Chemical Property of dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate

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Technology Process of dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate

There total 2 articles about dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

: 110-87-2
3,4-dihydro-2H-pyran

: 98890-11-0
dimethyl O^2'-benzoylgriseolate

: 98890-12-1
dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; for 2.5h; Ambient temperature;
DOI:10.1248/cpb.35.4442

Reference yield:

: 98871-18-2
O^2'-benzoylgriseolic acid

: 98890-12-1
dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate

Guidance literature:: Multi-step reaction with 2 steps

1: 45.6 percent / benzoyl chloride / methanol / 1 h; 26 h, r.t.

2: 87.6 percent / p-toluenesulfonic acid / dioxane / 2.5 h / Ambient temperature

With benzoyl chloride; toluene-4-sulfonic acid; In 1,4-dioxane; methanol;
DOI:10.1248/cpb.35.4442

Reference yield:

: 98890-12-1
dimethyl O^2'-benzoyl-O^7'-(tetrahydropyran-2-yl)griseolate

: 98940-85-3
dibenzhydryl 2'-deoxygriseolate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 1 N aqueous sodium hydroxide; 2.) 3 N hydrochloric acid / 1) pH=7, r.t., 20 h; 2.) acetone, water, pH from 1.5 to 3,darkness

2: 70.6 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / Ambient temperature

3: lithium iodide / hexamethylphosphoric acid triamide / Ambient temperature

4: pyridine p-toluenesulfonate / CH₂Cl₂; ethanol / 8 h / 60 °C

5: 96.3 percent / α,α'-azobisisobutyronitrile, tributyltin hydride / benzene / 0.75 h / Heating

With hydrogenchloride; dmap; sodium hydroxide; azobisisobutyronitrile; tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate; lithium iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; benzene;
DOI:10.1248/cpb.35.4442