Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester

Base Information

• Chemical Name: Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester
• CAS No.: 60352-71-8
• Molecular Formula: C₁₉H₂₇NO₄
• Molecular Weight: 333.428

Synonyms:Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester

Chemical Property of Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester

Chemical Property:

Purity/Quality:

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Technology Process of Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester

There total 31 articles about Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.2%

acetic anhydride (108-24-7) + (±)-lasubine II (89771-49-3) → Acetic acid (2R,4R,9aR)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester (57907-27-4,60352-71-8,80324-17-0)

Guidance literature:

In pyridine; for 15h; Ambient temperature;

Reference yield:

3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2) + rel-(2R,4S,10R)-2-acetoxy-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizine (53425-27-7) → methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate (53510-38-6) + Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester (60352-71-8)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jo00347a036

Reference yield:

3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2) + rel-(2R,4S,10R)-2-acetoxy-4-(3,4-dimethoxy-6-iodophenyl)octahydro-4H-quinolizine (80696-99-7) → methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate (53510-38-6) + Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester (60352-71-8)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1021/jo00347a036

upstream raw materials:

3-(4-hydroxyphenyl)propionic acid methyl ester

rel-(2R,4S,10R)-2-acetoxy-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizine

rel-(2R,4S,10R)-2-acetoxy-4-(3,4-dimethoxy-6-iodophenyl)octahydro-4H-quinolizine

acetic anhydride

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