(S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one

Base Information

Chemical Name:(S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one
CAS No.:1623766-45-9
Molecular Formula:C₁₅H₁₉F₂NO₄
Molecular Weight:315.317
Hs Code.:

Synonyms:(S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one

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Chemical Property of (S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one

Chemical Property:

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Technology Process of (S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one

There total 5 articles about (S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1623766-39-1
(S)-4-(2,4-dimethoxybenzyl)-2-(hydroxymethyl)-1,4-oxazepan-5-one

: 1623766-45-9
(S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one

Guidance literature:: (S)-4-(2,4-dimethoxybenzyl)-2-(hydroxymethyl)-1,4-oxazepan-5-one; With oxalyl dichloride; In tetrahydrofuran; dimethyl sulfoxide; at -78 ℃; for 1h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 1.16667h;

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -78 - 20 ℃; for 15h;

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1623766-45-9
(S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis(trifluoromethane)sulfonimide lithium / dichloromethane / 20 h / 20 °C / Cooling

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: pyridinium p-toluenesulfonate / 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux

4.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol; water; acetic acid / 50 h / 70 °C / 30003 - 37503.8 Torr

5.1: oxalyl dichloride / tetrahydrofuran; dimethyl sulfoxide / 1 h / -78 °C / Inert atmosphere

5.2: 1.17 h / 20 °C

5.3: 15 h / -78 - 20 °C

With oxalyl dichloride; 20% palladium hydroxide-activated charcoal; hydrogen; pyridinium p-toluenesulfonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bis(trifluoromethane)sulfonimide lithium; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 937174-97-5
(S)-1-(benzyloxy)-3-((2,4-dimethoxybenzyl)amino)propan-2-ol

: 1623766-45-9
(S)-2-(difluoromethyl)-4-(2,4-dimethoxybenzyl)-1,4-oxazepan-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: pyridinium p-toluenesulfonate / 5,5-dimethyl-1,3-cyclohexadiene / 6 h / Reflux

3.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethanol; water; acetic acid / 50 h / 70 °C / 30003 - 37503.8 Torr

4.1: oxalyl dichloride / tetrahydrofuran; dimethyl sulfoxide / 1 h / -78 °C / Inert atmosphere

4.2: 1.17 h / 20 °C

4.3: 15 h / -78 - 20 °C

With oxalyl dichloride; 20% palladium hydroxide-activated charcoal; hydrogen; pyridinium p-toluenesulfonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;