Technology Process of (2'R,3'S)-2-{3'-[2'',5''-bis(methoxymethoxy)phenyl]-2',3'-dihydroxyprop-2-enylsulfonyl}-1,3-benzothiazole
There total 8 articles about (2'R,3'S)-2-{3'-[2'',5''-bis(methoxymethoxy)phenyl]-2',3'-dihydroxyprop-2-enylsulfonyl}-1,3-benzothiazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 10 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
2.2: 1 h / 0 °C
3.1: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -78 - 0 °C
4.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 10 h / 0 - 20 °C
5.1: AD-mix-α; methanesulfonamide / tert-butyl alcohol; water / 12 h / 0 °C
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / -78 °C
With
methanesulfonamide; AD-mix-α; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; hexane; dichloromethane; water; acetone; toluene; mineral oil; tert-butyl alcohol;
2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/ejoc.201301269
- Guidance literature:
-
C20H21NO4S2;
With
methanesulfonamide; (DHQ)2PHAL;
In
water; tert-butyl alcohol;
at 0 ℃;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at -78 ℃;
DOI:10.1016/j.ejmech.2016.11.015