N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide

Base Information

• Chemical Name: N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide
• CAS No.: 1001340-67-5
• Molecular Formula: C₂₄H₂₈N₆O₂
• Molecular Weight: 432.525

Synonyms:N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide

Chemical Property of N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide

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Technology Process of N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide

There total 1 articles about N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-nitro-o-toluic acid (1975-52-6) → N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide (1001340-67-5)

Guidance literature:

5-nitro-o-toluic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In dichloromethane; at 20 ℃; for 0.5h;

With hydrogen; palladium 10% on activated carbon; In methanol; at 62 ℃; for 1.03333h;

Reference yield: 10.0%

N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide (1001340-67-5) + trifluoroacetic anhydride (407-25-0) → 5-(2,2,2-trifluoroacetamido)-N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-2-methylbenzamide hydrochloride

Guidance literature:

N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide; trifluoroacetic anhydride; In dichloromethane; at 20 ℃;

With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 0.0833333h;

Reference yield: 6.0%

N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide (1001340-67-5) + benzoyl chloride (98-88-4) → C31H32N6O3*ClH

Guidance literature:

N-(2-(3-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-5-amino-2-methylbenzamide; benzoyl chloride; In dichloromethane; at 20 ℃;

With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 0.0833333h;

upstream raw materials:

5-nitro-o-toluic acid

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