1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester
• CAS No.: 960287-20-1
• Molecular Formula: C₃₄H₃₈O₈
• Molecular Weight: 574.671
• Mol file: 960287-20-1.mol

Synonyms:1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester

Chemical Property of 1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester

There total 10 articles about 1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H34O8 (960287-24-5) → 1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester (960287-20-1)

Guidance literature:

With hydrogen; Wilkinson's catalyst; In toluene; at 20 ℃; for 15h; under 2280.15 Torr;

DOI:10.1055/s-2007-986652

Reference yield:

1-(2-hydroxymethyl-6-methoxybenzyl)-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester (954416-16-1) → 1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester (960287-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi / Ti(OiPr)3Cl / tetrahydrofuran; hexane / 1.5 h / -60 °C

1.2: 305 mg / tetrahydrofuran / -60 - -20 °C

2.1: 298 mg / hydrogen / Rh(PPh₃)3Cl / toluene / 15 h / 20 °C / 2280.15 Torr

With n-butyllithium; hydrogen; triisopropoxytitanium(IV) chloride; Wilkinson's catalyst; In tetrahydrofuran; hexane; toluene; 1.1: Swern oxidation;

DOI:10.1055/s-2007-986652

Reference yield:

tert-butyl 1-(2'-formyl-6'-methoxybenzyl)-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate (954416-17-2) → 1-[2-(1,6-dihydroxyhexyl)-6-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester (960287-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / Ti(OiPr)3Cl / tetrahydrofuran; hexane / 1.5 h / -60 °C

1.2: 305 mg / tetrahydrofuran / -60 - -20 °C

2.1: 298 mg / hydrogen / Rh(PPh₃)3Cl / toluene / 15 h / 20 °C / 2280.15 Torr

With n-butyllithium; hydrogen; triisopropoxytitanium(IV) chloride; Wilkinson's catalyst; In tetrahydrofuran; hexane; toluene;

DOI:10.1055/s-2007-986652

upstream raw materials:

C₃₄H₃₄O₈

1-(2-hydroxymethyl-6-methoxybenzyl)-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid tert-butyl ester

tert-butyl 1-(2'-formyl-6'-methoxybenzyl)-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate

tert-butyl 3-(trimethylsilyloxy)-2-(1'-(trimethylsilyloxy)vinyl)but-2-enoate

Downstream raw materials:

tert-butyl 1-[2'-(5''-carboxypentanoyl)-6'-methoxybenzyl]-3-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate