(4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol

Base Information

Chemical Name:(4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol
CAS No.:250668-96-3
Molecular Formula:C₂₂H₃₇NO₃Si
Molecular Weight:391.626
Hs Code.:

Synonyms:(4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol

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Chemical Property of (4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol

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Technology Process of (4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol

There total 4 articles about (4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 106-95-6
allyl bromide

: 250668-94-1
(2S,3S)-3-methyl-2-[N-(tert-butoxycarbonyl)amino]pentanoyldimethylphenylsilane

: 250668-96-3
(4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol

Guidance literature:: With indium; In tetrahydrofuran; at 20 ℃; for 15h;
DOI:10.1021/jo982501x

Reference yield: 60.0%

: 7393-43-3
tetraallyl tin

: 250668-94-1
(2S,3S)-3-methyl-2-[N-(tert-butoxycarbonyl)amino]pentanoyldimethylphenylsilane

: 250668-96-3
(4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jo982501x

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 250668-96-3
(4R,5S,6S)-5-[N-(tert-butoxycarbonyl)amino]-4-[dimethyl(phenyl)silyl]-6-methyl-1-octen-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / tetrahydrofuran / 0.5 h / 20 °C

2: 2.88 g / tetrahydrofuran / 0.5 h / -78 °C

3: 60 percent / scandium(III) triflate / CH₂Cl₂ / 24 h / 20 °C

With scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution / 3: Addition;
DOI:10.1021/jo982501x