1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide

Base Information

• Chemical Name: 1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide
• CAS No.: 24136-79-6
• Molecular Formula: C₂₅H₂₇N₂O*I
• Molecular Weight: 498.407
• Mol file: 24136-79-6.mol

Synonyms:1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide

Chemical Property of 1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide

There total 6 articles about 1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,2,3,3-tetramethyl-3H-indolium iodide (5418-63-3) + acetic anhydride (108-24-7) + glutacondianil hydrochloride (1497-49-0) → 1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide (24136-79-6)

Guidance literature:

With pyridine; at 25 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1021/ja107193j

Reference yield: 87.0%

5-anilino-penta-2,4-dienal-phenylimine (5608-83-3) + 1,2,3,3-tetramethyl-3H-indolium iodide (5418-63-3) + acetyl chloride (75-36-5) → 1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide (24136-79-6)

Guidance literature:

In acetic anhydride; at 110 ℃; for 0.5h;

DOI:10.1021/ja903685b

Reference yield: 54.0%

1,2,3,3-tetramethyl-3H-indolium iodide (5418-63-3) + glutacondianil hydrochloride (1497-49-0) + acetic acid (64-19-7,77671-22-8) → 1,3,3-trimethyl-2-(6-(N-phenylacetamido)hexa-1,3,5-trienyl)-3H-indolium iodide (24136-79-6)

Guidance literature:

at 100 ℃; for 1h;

upstream raw materials:

5-anilino-penta-2,4-dienal-phenylimine

1,2,3,3-tetramethyl-3H-indolium iodide

acetyl chloride

2,3,3-trimethylindoleniune

Refernces

• 1、 -. "Cyanine compound for labeling biomolecule and preparation method thereof". Page/Page column 46; 47. . Retrieved 2014/05/25.
• 2、 Berezin, Mikhail Y.,Guo, Kevin,Teng, Bao,Edwards, W. Barry,Anderson, Carolyn J.,Vasalatiy, Olga,Gandjbakhche, Amir,Griffiths, Gary L.,Achilefu, Samuel. "Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye". supporting information; experimental part. p. 9198 - 9200. Retrieved 2009/12/05.