ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate

Base Information

Chemical Name:ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate
CAS No.:1126736-32-0
Molecular Formula:C₂₀H₂₇NO₅
Molecular Weight:361.438
Hs Code.:

Synonyms:ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate

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Chemical Property of ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate

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Technology Process of ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate

There total 6 articles about ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1126736-29-5
(4S,3R)-N-Boc-3-benzyl-3-ethoxycarbonyl-4-hydroxypiperidine

: 1126736-32-0
ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol8029214

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 1126736-32-0
ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate

: C₂₀H₂₇NO₅

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / para-xylene; water / 0.5 h / 20 °C

1.2: 12 h / 20 °C

2.1: palladium on activated charcoal; hydrogen / ethanol / 12 h / 20 °C

3.1: triethylamine; dmap / dichloromethane / 0.25 h / 20 °C

With dmap; palladium on activated charcoal; hydrogen; triethylamine; potassium hydroxide; In ethanol; dichloromethane; para-xylene; water;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1126736-42-2
(R)-3-benzyl-4-oxopiperidine-3-carboxylic acid ethyl ester

: 1126736-32-0
ethyl (R)-3-benzyl-1-(tert-butyl)oxycarbonyl-4-oxopiperidine-3-carboxylate

: C₂₀H₂₇NO₅

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 25 ℃; Overall yield = 87 %; Overall yield = 122 mg;
DOI:10.1080/00397911.2018.1496259