N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide

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Chemical Name:N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide
CAS No.:104576-54-7
Molecular Formula:C₂₇H₃₁N₇O₅
Molecular Weight:533.587
Hs Code.:

Synonyms:N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide

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Chemical Property of N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide

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Technology Process of N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide

There total 3 articles about N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 104576-52-5
8-<4-<<<<4-(carboxymethyl)anilino>carbonyl>methyl>oxy>phenyl>-1,3-diethylxanthine methyl ester

: 107-15-3,85404-18-8
ethylenediamine

: 104576-54-7
N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide

Guidance literature:: at 50 ℃;
DOI:10.1021/jm00384a037

Reference yield:

: 83528-16-9
methyl 2-(4-aminophenyl)acetate hydrochloride

: 104576-54-7
N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide

2: 77 percent / 50 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00384a037

Reference yield:

: 104576-44-5
[4-(1,3-Diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetic acid

: 104576-54-7
N-{4-[(2-Amino-ethylcarbamoyl)-methyl]-phenyl}-2-[4-(1,3-diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide

2: 77 percent / 50 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00384a037