diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

Base Information

Chemical Name:diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate
CAS No.:76807-60-8
Molecular Formula:C₂₅H₃₁N₇O₅
Molecular Weight:509.565
Hs Code.:

Synonyms:diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

Suppliers and Price of diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

There total 7 articles about diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2378-95-2
diethyl N-<4-(methylamino)benzoyl>-L-glutamate

: 76807-56-2
2,4-diamino-6-(bromomethyl)pyrido<3,2-d>pyrimidine

: 76807-60-8
diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

Guidance literature:: In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.09.027

Reference yield:

: 76807-55-1
6-(Acetoxymethyl)-2,4-dichloropyrido<3,2-d>pyrimidine

: 76807-60-8
diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / liquid NH₃ / 18 h / 160 - 170 °C

2: PBr₃ / tetrahydrofuran / 8 h

3: N,N-dimethyl-acetamide / 6 h / Heating

With ammonia; phosphorus tribromide; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1021/jo00322a004

Reference yield:

: 76807-54-0
6-(Acetoxymethyl)-2,4-dioxopyrido<3,2-d>pyrimidine

: 76807-60-8
diethyl N-[4-[(2,4-diaminopyrido[3,2-d]pyrimidin-6-ylmethyl)methylamino]benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / POCl₃, (C₂H₅)3N / 8 h / Heating

2: 84 percent / liquid NH₃ / 18 h / 160 - 170 °C

3: PBr₃ / tetrahydrofuran / 8 h

4: N,N-dimethyl-acetamide / 6 h / Heating

With ammonia; phosphorus tribromide; triethylamine; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1021/jo00322a004