N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid

Base Information

Chemical Name:N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid
CAS No.:1416159-63-1
Molecular Formula:C₂₈H₃₃N₇O₇S
Molecular Weight:611.679
Hs Code.:

Synonyms:N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid

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Chemical Property of N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid

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Technology Process of N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid

There total 7 articles about N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.5%

: 1416159-59-5
diethyl N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamate

: 1416159-63-1
N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.09.027

Reference yield:

: 2378-95-2
diethyl N-<4-(methylamino)benzoyl>-L-glutamate

: 1416159-63-1
N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl acetamide / 2 h / 20 °C

2: platinum(IV) oxide; acetic acid; hydrogen / ethanol / 48 h / 20 °C / 3000.3 Torr

3: triethylamine / acetonitrile / 10 h / 20 °C

4: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

With platinum(IV) oxide; hydrogen; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl acetamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.09.027

Reference yield:

: 76807-54-0
6-(Acetoxymethyl)-2,4-dioxopyrido<3,2-d>pyrimidine

: 1416159-63-1
N-[4-[2-(2,4-diamino-5-tosyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-ylmethyl) methylamino]benzoyl]-L-glutamatic acid

Guidance literature:: Multi-step reaction with 7 steps

1: trichlorophosphate; triethylamine / Reflux

2: ammonia / methanol / 150 °C / Sealed tube

3: phosphorus tribromide

4: N,N-dimethyl acetamide / 2 h / 20 °C

5: platinum(IV) oxide; acetic acid; hydrogen / ethanol / 48 h / 20 °C / 3000.3 Torr

6: triethylamine / acetonitrile / 10 h / 20 °C

7: sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

With platinum(IV) oxide; ammonia; hydrogen; phosphorus tribromide; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl acetamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.09.027