(R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione

Base Information

Chemical Name:(R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione
CAS No.:1203834-92-7
Molecular Formula:C₁₄H₁₈N₂O₆S
Molecular Weight:342.373
Hs Code.:

Synonyms:(R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione

Chemical Property:

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Technology Process of (R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione

There total 10 articles about (R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1203835-05-5
(R)-1-(benzyloxy)-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione

: 1203834-92-7
(R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 3h; under 1125.11 Torr;
DOI:10.1021/jm200593b

Reference yield:

: 1092690-91-9
N-(4-methoxybenzenesulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

: 1203834-92-7
(R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 1125.11 Torr

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm200593b

Reference yield:

: 1092690-88-4
N-(4-methoxybenzenesulfonyl)-N-tert-butoxycarbonylmethyl-D-valine

: 1203834-92-7
(R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0 °C

2: methanol / 0 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 1125.11 Torr

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm200593b