[5-Hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-YL]acetonitrile

Base Information

Chemical Name:[5-Hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-YL]acetonitrile
CAS No.:551001-11-7
Molecular Formula:C₁₆H₁₁NO₃
Molecular Weight:265.268
Hs Code.:
UNII:7B877S86BL
DSSTox Substance ID:DTXSID801210731
Nikkaji Number:J2.117.255C
Wikidata:Q27095832
Pharos Ligand ID:UQ9MB5JKU6A7
Metabolomics Workbench ID:150112
ChEMBL ID:CHEMBL184151

Synonyms:[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE;WAY-244;WAY244;7B877S86BL;5-Hydroxy-2-(4-hydroxyphenyl)-7-benzofuranacetonitrile;UNII-7B877S86BL;CHEMBL184151;551001-11-7;7-Benzofuranacetonitrile, 5-hydroxy-2-(4-hydroxyphenyl)-;2-(2-(4-Hydroxyphenyl)-5-oxidanyl-1-benzofuran-7-yl)ethanenitrile;2-(5-Hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl)acetonitrile;[5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-yl]-acetonitrile;1x7e;SCHEMBL3925053;1x78;DTXSID801210731;BDBM50152615;DB06927;Q27095832

Suppliers and Price of [5-Hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-YL]acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [5-Hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-YL]acetonitrile

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:265.07389321
Heavy Atom Count:20
Complexity:382

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC3=CC(=CC(=C3O2)CC#N)O)O

Technology Process of [5-Hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-YL]acetonitrile

There total 5 articles about [5-Hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-YL]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 551001-27-5
7-Bromomethyl-2-(4-hydroxy-phenyl)-benzofuran-5-ol

: 551001-11-7
[5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl]acetonitrile

Guidance literature:: 18-crown-6 ether; In N-methyl-acetamide;

Reference yield:

: 551001-26-4
[5-Methoxy-2-(4-methoxy-phenyl)-benzofuran-7-yl]-methanol

: 551001-11-7
[5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl]acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: BBr₃ / CH₂Cl₂

2: dimethylformamide

With boron tribromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.07.029

Reference yield:

: 551002-47-2
5-methoxy-2-(4-methoxy-phenyl)-benzofuran-7-carboxylic acid methyl ester

: 551001-11-7
[5-hydroxy-2-(4-hydroxyphenyl)-1-benzofuran-7-yl]acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran

2: BBr₃ / CH₂Cl₂

3: dimethylformamide

With lithium aluminium tetrahydride; boron tribromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.07.029