N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide

Base Information

Chemical Name:N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide
CAS No.:1637586-55-0
Molecular Formula:C₂₀H₂₁F₂N₃O₃
Molecular Weight:389.402
Hs Code.:

Synonyms:N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide

Chemical Property:

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Technology Process of N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide

There total 5 articles about N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1637586-83-4
C₂₀H₁₉F₂N₃O₅

: 1637586-55-0
N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide

Guidance literature:: With tin(II) chloride dihdyrate; In ethanol; water; at 80 ℃; for 1.5h;
DOI:10.3390/molecules19056163

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1637586-55-0
N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 4 h / 60 °C

2: dichloromethane / 3 h / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

4: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

With dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; acetone;
DOI:10.3390/molecules19056163

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1637586-55-0
N-(1-(4-aminobenzyl)piperidin-4-yl)-2,2-difluorobenzo[d][1,3]dioxole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 4 h / 60 °C

2: dichloromethane / 3 h / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

4: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

With dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; acetone;
DOI:10.3390/molecules19056163