ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate

Base Information

• Chemical Name: ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate
• CAS No.: 1198420-35-7
• Molecular Formula: C₂₄H₂₁Cl₂NO₄
• Molecular Weight: 458.341
• Mol file: 1198420-35-7.mol

Synonyms:ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate

Chemical Property of ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate

There total 4 articles about ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl (4-{[(2-chloro-6-hydroxyphenyl)carbonyl]amino}phenyl)acetate (1198420-32-4) + 1-bromomethyl-3-chlorobenzene (766-80-3) → ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate (1198420-35-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

2-chloro-6-methoxybenzoic acid (3260-89-7) → ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate (1198420-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 3 h / 60 °C

1.2: 1 h / 60 °C

2.1: boron tribromide / dichloromethane / -78 - 0 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With thionyl chloride; boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

6-methoxyanthranilic acid (53600-33-2) → ethyl (4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetate (1198420-35-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tert.-butylnitrite; copper dichloride / acetonitrile / 18.08 h / Inert atmosphere

1.2: pH ~ 14

1.3: pH ~ 1

2.1: thionyl chloride / 3 h / 60 °C

2.2: 1 h / 60 °C

3.1: boron tribromide / dichloromethane / -78 - 0 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With thionyl chloride; tert.-butylnitrite; boron tribromide; potassium carbonate; copper dichloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

ethyl (4-{[(2-chloro-6-hydroxyphenyl)carbonyl]amino}phenyl)acetate

1-bromomethyl-3-chlorobenzene

2-chloro-6-methoxybenzoic acid

6-methoxyanthranilic acid

Downstream raw materials:

(4-{[(2-chloro-6-{[(3-chloro-phenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid