(Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid

Base Information

• Chemical Name: (Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid
• CAS No.: 158497-97-3
• Molecular Formula: C₃₅H₄₆O₆Si
• Molecular Weight: 590.832

Synonyms:(Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid

Chemical Property of (Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid

There total 20 articles about (Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(Z)-(3R,4S,7S,8R)-7-Acetoxy-9-(tert-butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid (158497-96-2) → (Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid (158497-97-3)

Guidance literature:

With potassium carbonate; Ambient temperature;

DOI:10.1021/ja00091a082

Reference yield:

(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal (91751-24-5,92817-88-4,123284-89-9,112897-04-8) → (Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid (158497-97-3)

Guidance literature:

Multi-step reaction with 7 steps

1: CrCl₂, NiCl₂ / tetrahydrofuran / 4 h / Ambient temperature

2: H₂ / Pd(CaCO₃, Pb) / benzene / 760 Torr / Ambient temperature

3: DMAP, pyridine / Ambient temperature

4: PPTS / CH₂Cl₂; methanol / Ambient temperature

5: Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

6: NaClO₂ / 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

7: 87 percent / methanolic K₂CO₃ / Ambient temperature

With pyridine; chromium dichloride; dmap; sodium chlorite; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; Dess-Martin periodane; nickel dichloride; palladium on calcium fluoride poisoned with lead; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol; benzene;

DOI:10.1021/ja00091a082

Reference yield:

(S)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol (95514-04-8,129029-85-2,120346-83-0) → (Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid (158497-97-3)

Guidance literature:

Multi-step reaction with 8 steps

1: Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

2: CrCl₂, NiCl₂ / tetrahydrofuran / 4 h / Ambient temperature

3: H₂ / Pd(CaCO₃, Pb) / benzene / 760 Torr / Ambient temperature

4: DMAP, pyridine / Ambient temperature

5: PPTS / CH₂Cl₂; methanol / Ambient temperature

6: Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

7: NaClO₂ / 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

8: 87 percent / methanolic K₂CO₃ / Ambient temperature

With pyridine; chromium dichloride; dmap; sodium chlorite; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; Dess-Martin periodane; nickel dichloride; palladium on calcium fluoride poisoned with lead; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol; benzene;

DOI:10.1021/ja00091a082

upstream raw materials:

(Z)-(3R,4S,7S,8R)-7-Acetoxy-9-(tert-butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid

(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

(S)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol

(R)-methyl 3-(tert-butyl(diphenyl)silyloxy)-2-methylpropanoate

Downstream raw materials:

(4R,5S,8S)-8-[(E)-(1R,2S,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-1,3,7-trimethyl-oct-3-enyl]-4-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-one

(4R,5S,8S)-8-[(E)-(1R,2R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-1,3,7-trimethyl-oct-3-enyl]-4-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-one

[4R-[4α,5α,8α(R*)]]-8-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-4-[(4-methoxyphenyl)methoxy]-5-methyl-2-oxocanone

(4R,5S,8S)-8-((S)-2-{(2S,3R)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-butyl]-2-methyl-oxiranyl}-1-methyl-2-oxo-ethyl)-4-(4-methoxy-benzyloxy)-5-methyl-oxocan-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 158497-97-3 (Z)-(3R,4S,7S,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-7-hydroxy-3-(4-methoxy-benzyloxy)-4,8-dimethyl-non-5-enoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send