Technology Process of (2S,3R,4R,5S,6R)-2-(4-chloro-3-((3,5-difluoro-4-methoxyphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
There total 6 articles about (2S,3R,4R,5S,6R)-2-(4-chloro-3-((3,5-difluoro-4-methoxyphenyl)methyl-d2)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylsilane; boron trifluoride diethyl etherate;
In
dichloromethane; acetonitrile;
at -78 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: aluminum (III) chloride / dichloromethane / 0 °C
1.2: 0 - 25 °C
1.3: 1 h / 25 °C
2.1: potassium carbonate / acetone / 25 °C
3.1: triethylsilane; trifluoroacetic acid / 0.17 h / 25 °C
3.2: 25 °C / Reflux
4.1: [D]-sodium hydroxide; tetrabutylammonium bisulfate; water-d2 / hexane; mineral oil / 25 °C
5.1: n-butyllithium / tetrahydrofuran; hexane; toluene / -65 °C
5.2: 2 h / -65 °C
5.3: 20 °C
6.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -78 - 20 °C
With
triethylsilane; aluminum (III) chloride; n-butyllithium; [D]-sodium hydroxide; tetrabutylammonium bisulfate; boron trifluoride diethyl etherate; water-d2; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; hexane; dichloromethane; acetone; toluene; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: [D]-sodium hydroxide; tetrabutylammonium bisulfate; water-d2 / hexane; mineral oil / 25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane; toluene / -65 °C
2.2: 2 h / -65 °C
2.3: 20 °C
3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -78 - 20 °C
With
triethylsilane; n-butyllithium; [D]-sodium hydroxide; tetrabutylammonium bisulfate; boron trifluoride diethyl etherate; water-d2;
In
tetrahydrofuran; hexane; dichloromethane; toluene; acetonitrile; mineral oil;
