21900-52-7

Basic information

• Product Name: 5-BROMO-2-CHLORO-BENZOYL CHLORIDE
• Synonyms: 5-BROMO-2-CHLORO-BENZOYL CHLORIDE;Benzoyl chloride, 5-bromo-2-chloro-
• CAS NO: 21900-52-7
• Molecular Formula: C₇H₃BrCl₂O
• Molecular Weight: 253.91
• Mol File: 21900-52-7.mol
• Article Data: 89

Chemical Properties

• Boiling Point: 281.4°C at 760 mmHg
• Flash Point: 124°C
• Appearance: /
• Density: 1.763g/cm³
• Vapor Pressure: 0.00357mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-BROMO-2-CHLORO-BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLORO-BENZOYL CHLORIDE(21900-52-7)
• EPA Substance Registry System: 5-BROMO-2-CHLORO-BENZOYL CHLORIDE(21900-52-7)

Safety Data

• Hazardous Substances Data: 21900-52-7(Hazardous Substances Data)

Usage

Uses

5-Bromo-2-chlorobenzoyl Chloride is an intermediate in the synthesis of labelled and unlabelled isotopes of glucuronide metabolites of dapagliflozin. It also functions as an intermediate in the synthesis of dapagliflozin, a potent and selective hSGLT2 inhibitor.

InChI:InChI=1/C7H3BrCl2O/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H

Upstream product

• 99-52-5 2-methyl-4-nitro-benzenamine 
• 5781-53-3 monomethyl oxalyl chloride 
• 106-39-8 bromochlorobenzene 
• 79-37-8 oxalyl dichloride 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 
• 54932-72-8 2-chloro-5-bromotoluene 

Downstream Products

• 201686-71-7 6-[bis-(5-bromo-2-chloro-benzoyl)-amino]-nicotinic acid ethyl ester 
• 127767-42-4 2-(5-bromo-2-chloro-phenyl)-6-methyl-chromen-4-one 
• 301672-80-0 5-bromo-2-chloro-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)benzamide 
• 435273-54-4 5-bromo-2-chloro-N-methylbenzamide 
• 879545-43-4 (5-bromo-2-chlorophenyl)(4-ethylphenyl)methanone 
• 879545-44-5 (5-bromo-2-chlorophenyl)(2-ethylphenyl)methanone 
• 915095-85-1 (5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone 
• 669734-35-4 5-bromo-2-chloro-N-cyclopropylbenzamide 
• 461432-22-4 (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone 
• 1210040-58-6 (5-bromo-2-chlorophenyl)(4-(2,2-dibromocyclopropyl)phenyl)methanone 
• 1154956-96-3 2-chloro-5-bromo-4'-isopropylbenzophenone 
• 1096824-35-9 C₁₇H₁₆BrClO 
• 333361-39-0 C₁₄H₁₀BrClOS 
• 842135-04-0 C₁₃H₁₀BrClOS 

Relevant articles and documents

Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13

Empagliflozin, (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5- triol was recently approved by the FDA for the treatment of chronic type 2 diabetes mellitus. Herein, we report the synthesis of car

Synthetic method of empagliflozin

The invention provides a brand-new synthesis process of empagliflozin. According to the process, a boric acid ester is used for halogen removal, and specific reaction conditions are combined, so thatempagliflozin can be prepared with high yield and simplicity and convenience in operation. The synthesis method of empagliflozin has the advantages of mild reaction conditions, high total yield, few side reactions and convenience in operation, thereby being beneficial to industrial production and cost control.

Preparation method of 5-bromo-2-chloro-4'-ethoxybenzophenone

The invention discloses a preparation method of 5-bromo-2-chloro-4'-ethoxybenzophenone, and belongs to the technical field of medicine synthesis. The preparation method comprises the following steps:(1) carrying out direct reflux reaction on 5-bromo-2-chlorobenzoic acid and thionyl chloride in the absence of a solvent under the catalysis of DMF, and evaporating excessive thionyl chloride to obtain 5-bromo-2-chlorobenzoyl chloride after the reaction is finished; (2) adding dichloromethane into the material obtained in the step (1) for dissolving, directly adding silica gel loaded aluminum trichloride, performing reacting with phenethyl ether under a vacuum condition, performing filtering after the reaction is completed, washing the filtrate with a 5% sodium bicarbonate solution and water in sequence, performing evaporating to remove the solvent, and performing recrystallizing with a mixed solvent of ethanol and water to obtain 5-bromo-2-chloro-4'-ethoxybenzophenone. The method providedby the invention has the advantages of the small acid solvent generation amount, less difficult-to-treat wastewater, high product purity and yield, no generation of by-products, environmental protection, simple operation, and suitability for industrial production and popularization.