(S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

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Chemical Name:(S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester
CAS No.:82136-18-3
Molecular Formula:C₃₉H₅₂N₈O₁₂S
Molecular Weight:856.954
Hs Code.:

(S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

Synonyms:(S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

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Chemical Property of (S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

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Technology Process of (S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

There total 10 articles about (S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15387-45-8
Boc-Gln-ONp

: 82136-18-3
(S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / 1-hydroxybenzotriazole / dimethylformamide / 0.5 h / 25 °C

2: trifluoroacetic acid; CH₂Cl₂ / 0.5 h / 25 °C

3: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

4: trifluoroacetic acid; CH₂Cl₂ / 0.5 h / 25 °C

5: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

With 4-methyl-morpholine; benzotriazol-1-ol; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/ja00379a056

Reference yield:

: 7175-34-0,86070-35-1
Asn-NH-CH₃

: 82136-18-3
(S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / 1-hydroxybenzotriazole / dimethylformamide / 0.5 h / 25 °C

2: trifluoroacetic acid; CH₂Cl₂ / 0.5 h / 25 °C

3: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

4: trifluoroacetic acid; CH₂Cl₂ / 0.5 h / 25 °C

5: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

With 4-methyl-morpholine; benzotriazol-1-ol; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1021/ja00379a056

Reference yield:

: 61925-77-7
Boc-cysteine(4-Me-Bn)

: 82136-18-3
(S)-4-{2-[(R)-2-(2-Acetylamino-acetylamino)-3-(4-methyl-benzylsulfanyl)-propionylamino]-acetylamino}-4-[(S)-3-carbamoyl-1-((S)-1-carboxy-2-methylcarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

2: trifluoroacetic acid; CH₂Cl₂ / 0.5 h / 25 °C

3: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

4: 72 percent / 0.1M NaOH / methanol; H₂O / 3 h / 25 °C

5: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In methanol; dichloromethane; water; trifluoroacetic acid;
DOI:10.1021/ja00379a056