(1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid

Base Information

Chemical Name:(1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid
CAS No.:1596364-69-0
Molecular Formula:C₃₁H₃₃NO₆Si
Molecular Weight:543.692
Hs Code.:

Synonyms:(1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid

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Chemical Property of (1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid

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Technology Process of (1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid

There total 5 articles about (1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1596364-68-9
2-((1R,2S,3R,4R)-3-((tert-butyldiphenylsilyl)oxy)-4-(hydroxymethyl)-2-methoxycyclopentyl)isoindoline-1,3-dione

: 1596364-69-0
(1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid

Guidance literature:: With sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; acetonitrile; for 1h;

Reference yield:

: 1596364-65-6
2-(1R,2S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-2-methoxycyclopentylisoindoline-1,3-dione

: 1596364-69-0
(1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / N,N-dimethyl-formamide / 22 h / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

3: pyridinium p-toluenesulfonate / ethanol / 18 h / 50 °C

4: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 1 h

With 1H-imidazole; dmap; sodium periodate; ruthenium(III) trichloride hydrate; pyridinium p-toluenesulfonate; In tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1596364-67-8
2-((1R,2S,3R,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-3-((tert-butyldiphenylsilyl)oxy)-2-methoxycyclopentyl)isoindoline-1,3-dione

: 1596364-69-0
(1S,2R,3S,4R)-2-((tert-butyldiphenylsilyl)oxy)-4-(1,3-dioxoisoindolin-2-yl)-3-methoxycyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / ethanol / 18 h / 50 °C

2: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 1 h

With sodium periodate; ruthenium(III) trichloride hydrate; pyridinium p-toluenesulfonate; In tetrachloromethane; ethanol; water; acetonitrile;