ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

Base Information

Chemical Name:ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate
CAS No.:93662-05-6
Molecular Formula:C₂₂H₃₁N₅O₆
Molecular Weight:461.518
Hs Code.:

Synonyms:ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

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Chemical Property of ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

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Technology Process of ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

There total 3 articles about ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 93662-05-6
ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / triethylorthoformate, TsOH / 1 h / Heating

2: 87 percent / K₂CO₃ / dimethylformamide / 6 h / 120 °C

3: 86 percent / 2 N HCl / tetrahydrofuran / 1 h / 50 °C

4: 1) n-BuLi, diisopropylamine / 1) hexane, THF, toluene, -60 deg; 2) hexane, toluene, THF, -60 deg C -->room temp.

With hydrogenchloride; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; diisopropylamine; orthoformic acid triethyl ester; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.1140

Reference yield:

: 98454-56-9
5-hydroxy-2-nitrobenzaldehyde ethylene acetal

: 93662-05-6
ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / K₂CO₃ / dimethylformamide / 6 h / 120 °C

2: 86 percent / 2 N HCl / tetrahydrofuran / 1 h / 50 °C

3: 1) n-BuLi, diisopropylamine / 1) hexane, THF, toluene, -60 deg; 2) hexane, toluene, THF, -60 deg C -->room temp.

With hydrogenchloride; n-butyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.1140

Reference yield:

: 98454-57-0
5-<4-(1-cyclohexy-1H-5-tetrazolyl)butoxy>-2-nitrobenzaldehyde ethylene acetal

: 93662-05-6
ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 2 N HCl / tetrahydrofuran / 1 h / 50 °C

2: 1) n-BuLi, diisopropylamine / 1) hexane, THF, toluene, -60 deg; 2) hexane, toluene, THF, -60 deg C -->room temp.

With hydrogenchloride; n-butyllithium; diisopropylamine; In tetrahydrofuran;
DOI:10.1248/cpb.33.1140