tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate
• CAS No.: 228260-15-9
• Molecular Formula: C₁₆H₂₁N₃O₃
• Molecular Weight: 303.361

Synonyms:tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate

Chemical Property of tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate

Chemical Property:

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Technology Process of tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate

There total 2 articles about tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methylazine + 2,3,4,5,6-pentafluorophenol (771-61-9) + (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoic acid (131724-45-3) → tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate (228260-15-9)

Guidance literature:

With 4-methyl-morpholine; In ethanol; dichloromethane;

Reference yield: 86.0%

methylamine hydrochloride (593-51-1) + (S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoic acid (131724-45-3) → tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate (228260-15-9)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2021.116223

Reference yield: 100.0%

tert-butyl (S)-(3-(4-cyanophenyl)-1-(methylamino)-1-oxopropan-2-yl)carbamate (228260-15-9) → (S)-2-amino-3-(4-cyanophenyl)-N-methylpropanamide hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 2h;

DOI:10.1016/j.bmc.2021.116223

upstream raw materials:

2,3,4,5,6-pentafluorophenol

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoic acid

methylamine hydrochloride

Downstream raw materials:

N-[4-hydroxy-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-cyanophenylalanine N-methylamide

N-[4-tert-butyloxy-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-cyanophenylalanine N-methylamide

N-[4-hydroxy-2(R)-isobutyl-3(S)-phenylpropylsuccinyl]-L-4'-[N,N'-bis(benzyloxycarbonyl)guanidinomethyl]phenylalanine N-methylamide

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