Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite

Base Information

Chemical Name:Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite
CAS No.:121373-20-4
Molecular Formula:C16H40 N O2 P Si2
Molecular Weight:365.644
Hs Code.:
European Community (EC) Number:802-305-1
DSSTox Substance ID:DTXSID40471952
Nikkaji Number:J634.050D
Wikidata:Q82300659
Mol file:121373-20-4.mol

Synonyms:121373-20-4;Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite;N-[bis(2-trimethylsilylethoxy)phosphanyl]-N-propan-2-ylpropan-2-amine;iPr2N-P-(OTSE)2;Bis(2-(trimethylsilyl)ethyl)-diisopropylphosphoramidite;UCVPTNNSVPPRRA-UHFFFAOYSA-N;Bis(2-(trimethylsilyl)ethyl)diisopropylphosphoramidite;SCHEMBL1578877;DTXSID40471952;AKOS016005309;HY-W608384;CS-0691038;FT-0757197;bis(2-trimethylsilylethoxy)(diisopropylamino)pho sphane;Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite;Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite, 96%;Diisopropyl-phosphoramidous acid bis-(2-trimethylsilanyl-ethyl) ester

Suppliers and Price of Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite 96%
25g
$ 602.00

Sigma-Aldrich
Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite 96%
5g
$ 364.00

Matrix Scientific
Bis(2-(trimethylsilyl)ethyl)-diisopropylphosphoramidite 95+%
5g
$ 840.00

Matrix Scientific
Bis(2-(trimethylsilyl)ethyl)-diisopropylphosphoramidite 95+%
1g
$ 284.00

Chemenu
bis(2-(trimethylsilyl)ethyl)diisopropylphosphoramidite 95%
5g
$ 371.00

AK Scientific
Bis(2-(trimethylsilyl)ethyl)diisopropylphosphoramidite
5g
$ 2048.00

AK Scientific
Bis(2-(trimethylsilyl)ethyl)diisopropylphosphoramidite
1g
$ 752.00

Total 12 raw suppliers

Chemical Property of Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite

Chemical Property:

Refractive Index:n20/D1.4517
Boiling Point:286.2-296.6°C
Flash Point:>110℃
PSA：35.29000
Density:0.8887 g/mL at 25 °C
LogP:6.04170
Storage Temp.:2-8°C
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:11
Exact Mass:365.23351959
Heavy Atom Count:22
Complexity:274

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)N(C(C)C)P(OCC[Si](C)(C)C)OCC[Si](C)(C)C
Uses Phosphitylation agent used in the preparation of oligonucleotides

Technology Process of Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite

There total 3 articles about Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 921-26-6
N,N-diisopropylphosphoramide dichloride

: 121373-20-4
N,N-Diisopropyl-bis<2-(trimethylsilyl)ethyl>phosphoramidite

Guidance literature:: With triethylamine; In diethyl ether; at -2 - 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm500026w

Reference yield: 97.6%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 121373-20-4
N,N-Diisopropyl-bis<2-(trimethylsilyl)ethyl>phosphoramidite

Guidance literature:: With N,N-diisopropylphosphoramide dichloride; triethylamine; In diethyl ether; at -2 - 20 ℃; Inert atmosphere;

Reference yield:

: 108-18-9
diisopropylamine

: 121373-20-4
N,N-Diisopropyl-bis<2-(trimethylsilyl)ethyl>phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: PCl₃

2: 16 percent / Et₃N / diethyl ether / 4 h / -78 °C

With triethylamine; phosphorus trichloride; In diethyl ether;
DOI:10.1039/P19950000421